MYOCARDIAL PERFUSION IMAGING WITH TC-99M-LABELED AGENTS

被引:21
作者
MADDAHI, J
KIAT, H
BERMAN, DS
机构
[1] UNIV CALIF LOS ANGELES, SCH MED, CTR CLIN POSITRON EMISS TOMOG, DEPT RADIOL SCI, LOS ANGELES, CA 90024 USA
[2] CEDARS SINAI MED CTR, DEPT MED, DIV CARDIOL, LOS ANGELES, CA 90048 USA
[3] CEDARS SINAI MED CTR, DEPT NUCL MED, LOS ANGELES, CA 90048 USA
关键词
D O I
10.1016/S0002-9149(05)80005-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thallium-201 (Tl-201) is suboptimal as a single-photon emitting agent for myocardial perfusion imaging, in view of its low-energy photons and long half-life. To circumvent these limitations, two new myocardial perfusion imaging agents labeled with technetium-99m (Tc-99m) have been developed. They are Tc-sestamibi and Tc-teboroxime. Clinical trials of myocardial perfusion with both tracers have shown results similar to those obtained with Tl-201 for detection of coronary artery disease. Results to date indicate that Tc-sestamibi accurately detects and locates myocardial infarction and can accurately assess both left and right ventricular ejection fractions by the first-pass technique. In addition, research has shown that rest-stress studies can be performed on the same day and that Tc-sestamibi can be used to assess the results of thrombolytic therapy. Tc-teboroxime has excellent myocardial tracer uptake characteristics but is cleared very rapidly from the myocardium. These features make Tc-teboroxime well suited to rapid serial studies. These new technetium myocardial perfusion agents have just become available for routine clinical use and are likely to replace Tl-201 in many of its clinical applications.
引用
收藏
页码:D27 / D34
页数:8
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