The aim of the present study was to identify cellular elements bearing high-affinity neurotensin (NT) binding sites in the suprachiasmatic nucleus (SCN) of the rat hypothalamus. Because the distribution of these binding sites had previously been reported to conform to that of both vasoactive intestinal peptide (VIP)-containing nerve cell bodies and serotonin (5-HT)-containing axons, the following experimental approaches were used: (1) the overlap between autoradiographically labeled NT binding sites and immunocytochemically labeled VIP neurons was examined in adjacent 5-mu-m-thick sections taken across the entire rostrocaudal extent of the SCN; and (2) the density of NT binding sites was examined by quantitative autoradiography following cytotoxic lesioning of 5-HT afferents. Double-labeling studies demonstrated precise overlap between I-125-NT binding and VIP immunostaining throughout the SCN. Moreover, at high magnification intensely VIP-immunoreactive neurons were found in direct register with I-125-NT-labeled cells visualized in adjacent sections. Densitometric autoradiographic studies demonstrated a significant reduction in specific I-125-NT binding within the SCN following intracerebroventricular injection of the neurotoxin, 5,7-dihydroxytryptamine. Taken together, these results indicate that within the SCN, NT receptors are present both presynaptically on serotonin axons and postsynaptically on the perikarya and dendrites of VIP-containing neurons.
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
MAZELLA, J
LEONARD, K
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
LEONARD, K
CHABRY, J
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
CHABRY, J
KITABGI, P
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
KITABGI, P
VINCENT, JP
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
VINCENT, JP
BEAUDET, A
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
MAZELLA, J
LEONARD, K
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
LEONARD, K
CHABRY, J
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
CHABRY, J
KITABGI, P
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
KITABGI, P
VINCENT, JP
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA
VINCENT, JP
BEAUDET, A
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MCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADAMCGILL UNIV, MONTREAL GEN HOSP, NEUROANAT LAB, MONTREAL H3G 1A4, QUEBEC, CANADA