THE CONSERVED ACID-BINDING DOMAIN MODEL OF INHIBITORS OF PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A - MOLECULAR MODELING ASPECTS

被引：45

作者：

QUINN, RJ ^{[1
]}

TAYLOR, C ^{[1
]}

SUGANUMA, M ^{[1
]}

FUJIKI, H ^{[1
]}

机构：

[1] NATL CANC CTR, RES INST, DIV CANC PREVENT, CHUO KU, TOKYO 104, JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80281-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using molecular modelling, three chemically distinct members of the okadaic acid class of protein phosphatase inhibitors and tumor promoters, okadaic acid, calyculin A and microcystin-LR were fitted together. The molecular modelling results indicate a pharmacophore model consisting of a central core, containing one conserved acidic group and two potential hydrogen bonding sites, and a non-polar side chain.

引用

页码：1029 / 1034

页数：6

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