EXPRESSION OF NEUROTROPHIN GENES IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE (SAM) DURING POSTNATAL-DEVELOPMENT

被引：20

作者：

KAISHO, Y

MIYAMOTO, M

SHIHO, O

ONOUE, H

KITAMURA, Y

NOMURA, S

机构：

[1] TAKEDA CHEM IND LTD,DIV PHARMACEUT RES,PHARMACEUT RES LABS 1,OSAKA 532,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT PATHOL,SUITA,OSAKA 565,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 647卷 / 01期

关键词：

SENESCENCE-ACCELERATED MOUSE; NERVE GROWTH FACTOR; NEUROTROPHIN; DEVELOPMENT; HIPPOCAMPUS; MESSENGER-RNA;

D O I：

10.1016/0006-8993(94)91408-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the expression patterns of neurotrophin genes in the brain of senescence-accelerated mouse (SAMP8) which shows age-related impairment of learning behavior, with SAMR1 control which shows normal aging. By Northern blot analysis, NT-3 mRNA levels in the cortex were higher in SAMP8 than in SAMR1 mice during development, whereas in the midbrain, hippocampus and forebrain, NT-3 expression levels in SAMP8 were lower than those in SAMR1. At early stages, although NGF mRNA levels in SAMP8 were lower than those in SAMR1, BDNF mRNA levels were almost equivalent in both strains. By in situ hybridization analysis, NT-3 mRNA signals in the CA1 and CA2 regions in SAMP8 were shown to be reduced at early stages. However, BDNF mRNA signals were almost equivalent in both SAMR1 and SAMP8.

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收藏

页码：139 / 144

页数：6

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