ISOLATION AND CHARACTERIZATION OF THE HUMAN MRE11 HOMOLOG

被引：115

作者：

PETRINI, JHJ

WALSH, ME

DIMARE, C

CHEN, XN

KORENBERG, JR

WEAVER, DT

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115

[3] UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,CTR MED GENET BIRTH DEFECTS,AHMANSON DEPT PEDIAT,LOS ANGELES,CA 90048

来源：

GENOMICS | 1995年 / 29卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1217

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mutation of the Saccharomyces cerevisiae RAD52 epistasis group gene, MRE11, blocks meiotic recombination, confers profound sensitivity to double-strand break damage, and has a hyperrecombinational phenotype in mitotic cells. We isolated a highly conserved human MRE11 homologue using a two-hybrid screen for DNA Ligase I-interacting proteins. Human MRE11 shares approximately 50% identity with its yeast counterpart over the N-terminal half of the protein. MRE11 is expressed at the highest levels in proliferating tissues, but is also observed in other tissues. The MRE11 locus maps to human chromosome 11q21 in a region frequently associated with cancer-related chromosomal abnormalities. A MRE11-related locus was found on chromosome 7q11.2-q11.3. (C) 1995 Academic Press Inc.

引用

页码：80 / 86

页数：7