RIBOZYMES

被引：49

作者：

SYMONS, RH

机构：

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(94)90099-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past year there has been increasing interest in the six naturally occurring ribozyme systems. The main emphasis has been on approaches to increase our understanding of the three-dimensional active conformation and the details of the reaction mechanism of these structures. There is continued interest in the application of the hammerhead system in vivo to control viral replication, especially in animal cells.

引用

页码：322 / 330

页数：9

共 50 条

[1] RECENT STUDIES OF RIBONUCLEASE-P
ALTMAN, S
KIRSEBOM, L
TALBOT, S
[J]. FASEB JOURNAL, 1993, 7 (01) : 7 - 14
[2] ESSENTIAL NUCLEOTIDE-SEQUENCES AND SECONDARY STRUCTURE ELEMENTS OF THE HAIRPIN RIBOZYME
BERZALHERRANZ, A
JOSEPH, S
CHOWRIRA, BM
BUTCHER, SE
BURKE, JM
[J]. EMBO JOURNAL, 1993, 12 (06) : 2567 - 2574
[3] DYNAMICS OF RIBOZYME BINDING OF SUBSTRATE REVEALED BY FLUORESCENCE-DETECTED STOPPED-FLOW METHODS
BEVILACQUA, PC
KIERZEK, R
JOHNSON, KA
TURNER, DH
[J]. SCIENCE, 1992, 258 (5086) : 1355 - 1357
[4] EFFICIENT TRANS-CLEAVAGE AND A COMMON STRUCTURAL MOTIF FOR THE RIBOZYMES OF THE HUMAN HEPATITIS-DELTA AGENT
BRANCH, AD
ROBERTSON, HD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) : 10163 - 10167
[5] BRUENING G, 1989, METHOD ENZYMOL, V180, P546
[6] STRUCTURAL CONVENTIONS FOR GROUP-I INTRONS
BURKE, JM
BELFORT, M
CECH, TR
DAVIES, RW
SCHWEYEN, RJ
SHUB, DA
SZOSTAK, JW
TABAK, HF
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (18) : 7217 - 7221
[7] INVITRO SELECTION AND EVOLUTION OF RNA - APPLICATIONS FOR CATALYTIC RNA, MOLECULAR RECOGNITION, AND DRUG DISCOVERY
BURKE, JM
BERZALHERRANZ, A
[J]. FASEB JOURNAL, 1993, 7 (01) : 106 - 112
[8] RIBOZYME CLEAVES REX TAX MESSENGER-RNA AND INHIBITS BOVINE LEUKEMIA-VIRUS EXPRESSION
CANTOR, GH
MCELWAIN, TF
BIRKEBAK, TA
PALMER, GH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 10932 - 10936
[9] IMPORTANT 2'-HYDROXYL GROUPS WITHIN THE CORE OF A GROUP-I INTRON
CAPRARA, MG
WARING, RB
[J]. BIOCHEMISTRY, 1993, 32 (14) : 3604 - 3610
[10] CECH TR, 1990, ANNU REV BIOCHEM, V59, P543, DOI 10.1146/annurev.biochem.59.1.543

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