ADHESION OF HUMAN CANCER-CELLS TO VASCULAR ENDOTHELIUM MEDIATED BY A CARBOHYDRATE ANTIGEN, SIALYL LEWIS-A

被引：335

作者：

TAKADA, A

OHMORI, K

TAKAHASHI, N

TSUYUOKA, K

YAGO, A

ZENITA, K

HASEGAWA, A

KANNAGI, R

机构：

[1] KYOTO UNIV,SCH MED,DEPT LAB MED,KYOTO 606,JAPAN

[2] GIFU UNIV,SCH AGR,DEPT APPL BIOORGAN CHEM,GIFU 51011,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91875-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently the lectin-like domain on ELAM-1 (endothelial leukocyte adhesion molecule-1) was shown to recognize a carbohydrate antigen, sialyl Lewis x. In this paper we demonstrate, by a series of inhibition experiments utilizing specific monoclonal antibodies and pure glycolipid preparations, that the sialyl Lewis a antigen serves as a specific ligand for ELAM-1 as well as sialyl Lewis x and plays a significant role in the ELAM-1-mediated binding of human cancer cells to activated andothelial cells. © 1991.

引用

页码：713 / 719

页数：7

共 24 条

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