VIRAL INVOLVEMENT IN HODGKINS-DISEASE - DETECTION OF CLONAL TYPE-A EPSTEIN-BARR-VIRUS GENOMES IN TUMOR SAMPLES

被引:79
作者
GLEDHILL, S
GALLAGHER, A
JONES, DB
KRAJEWSKI, AS
ALEXANDER, FE
KLEE, E
WRIGHT, DH
OBRIEN, C
ONIONS, DE
JARRETT, RF
机构
[1] UNIV GLASGOW,SCH VET,CTR LEUKAEMIA RES FUND VIRUS,DEPT VET PATHOL,BEARSDEN RD,GLASGOW G61 1QH,SCOTLAND
[2] UNIV SOUTHAMPTON,SOUTHAMPTON GEN HOSP,DEPT PATHOL,SOUTHAMPTON S09 4XY,ENGLAND
[3] UNIV EDINBURGH,SCH MED,DEPT PATHOL,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND
[4] UNIV LEEDS,LEUKAEMIA RES FUND CTR CLIN EPIDEMIOL,LEEDS LS2 9NG,W YORKSHIRE,ENGLAND
[5] UNIV LEEDS,DEPT PATHOL,LEEDS LS2 9NG,W YORKSHIRE,ENGLAND
关键词
D O I
10.1038/bjc.1991.281
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtype specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.
引用
收藏
页码:227 / 232
页数:6
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