CHOLECYSTOKININ RECEPTOR DENSITY IN THE STRIATUM OF THE SPONTANEOUSLY HYPERTENSIVE RAT

被引：5

作者：

KIROUAC, GJ ^{[1
]}

GANGULY, PK ^{[1
]}

机构：

[1] UNIV MANITOBA, FAC MED, DEPT ANAT, WINNIPEG R3T 2N2, MANITOBA, CANADA

来源：

BRAIN RESEARCH | 1993年 / 604卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

RECEPTOR AUTORADIOGRAPHY; CHOLECYSTOKININ; SPONTANEOUSLY HYPERTENSIVE RAT; STRIATUM;

D O I：

10.1016/0006-8993(93)90387-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possibility that cholecystokinin in the striatum may be involved in hypertension was investigated using in vitro receptor autoradiography. The binding density of I-125-Bolton Hunter labeled cholecystokinin octapeptide (I-125-BH-CCK8) was determined using computer-assisted densitometry in the striatum of the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto rat (WKY). A significant increase in I-125-BH-CCK8 binding density was found in the lateral part of the caudate-putamen of the SHR. In contrast, a significant decrease in I-125-BH-CCK8 binding density was found in the posteromedial nucleus accumbens of the SHR. These results indicate that CCK8 receptor density is altered in the striatum of the SHR and suggest a role for CCK8 receptors in the pathophysiology of hypertension.

引用

页码：338 / 341

页数：4

共 33 条

[1] INCREASE IN BRAIN I-125-LABELED CHOLECYSTOKININ (CCK) RECEPTOR-BINDING FOLLOWING CHRONIC HALOPERIDOL TREATMENT, INTRACISTERNAL 6-HYDROXYDOPAMINE OR VENTRAL TEGMENTAL LESIONS [J].

CHANG, RSL ;

LOTTI, VJ ;

MARTIN, GE ;

CHEN, TB .

LIFE SCIENCES, 1983, 32 (08) :871-878

[2] COMPARATIVE DISTRIBUTION OF CHOLECYSTOKININ AND OTHER NEUROPEPTIDES - WHY IS THIS PEPTIDE DIFFERENT FROM ALL OTHER PEPTIDES [J].

CRAWLEY, JN .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 448 (JUL) :1-8

[3] CHOLECYSTOKININ-DOPAMINE INTERACTIONS [J].

CRAWLEY, JN .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (06) :232-236

[4] DOPAMINE RECEPTOR ELEVATION BY CHOLECYSTOKININ [J].

DUMBRILLEROSS, A ;

SEEMAN, P .

PEPTIDES, 1984, 5 (06) :1207-1212

[5]

GILLIS RA, 1983, J PHARMACOL EXP THER, V224, P408

[6]

HOKFELT T, 1980, NEUROSCIENCE, V5, P2093, DOI 10.1016/0306-4522(80)90127-x

[7] EFFECTS OF STRESS ON RELEASE OF DOPAMINE AND SEROTONIN IN THE STRIATUM OF SPONTANEOUSLY HYPERTENSIVE RATS - AN INVIVO VOLTAMMETRIC STUDY [J].

IKEDA, M ;

HIRATA, Y ;

FUJITA, K ;

SHINZATO, M ;

TAKAHASHI, H ;

YAGYU, S ;

NAGATSU, T .

NEUROCHEMISTRY INTERNATIONAL, 1984, 6 (04) :509-512

[8]

JARROTT B, 1987, Journal of Cardiovascular Pharmacology, V10, pS14, DOI 10.1097/00005344-198710012-00003

[9] ANTINOCICEPTIVE EFFECT OF CENTRALLY ADMINISTERED CERULEIN AND CHOLECYSTOKININ OCTAPEPTIDE (CCK-8) [J].

JURNA, I ;

ZETLER, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 73 (04) :323-331

[10] EFFECT OF THE INTRACEREBROVENTRICULAR INJECTION OF DOPAMINE ON BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].

KAWABE, H ;

KONDO, K ;

SARUTA, T .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1983, 5 (10) :1703-1716

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