CHOLECYSTOKININ RECEPTOR DENSITY IN THE STRIATUM OF THE SPONTANEOUSLY HYPERTENSIVE RAT

被引：5

作者：

KIROUAC, GJ ^{[1
]}

GANGULY, PK ^{[1
]}

机构：

[1] UNIV MANITOBA, FAC MED, DEPT ANAT, WINNIPEG R3T 2N2, MANITOBA, CANADA

来源：

BRAIN RESEARCH | 1993年 / 604卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

RECEPTOR AUTORADIOGRAPHY; CHOLECYSTOKININ; SPONTANEOUSLY HYPERTENSIVE RAT; STRIATUM;

D O I：

10.1016/0006-8993(93)90387-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possibility that cholecystokinin in the striatum may be involved in hypertension was investigated using in vitro receptor autoradiography. The binding density of I-125-Bolton Hunter labeled cholecystokinin octapeptide (I-125-BH-CCK8) was determined using computer-assisted densitometry in the striatum of the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto rat (WKY). A significant increase in I-125-BH-CCK8 binding density was found in the lateral part of the caudate-putamen of the SHR. In contrast, a significant decrease in I-125-BH-CCK8 binding density was found in the posteromedial nucleus accumbens of the SHR. These results indicate that CCK8 receptor density is altered in the striatum of the SHR and suggest a role for CCK8 receptors in the pathophysiology of hypertension.

引用

页码：338 / 341

页数：4

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