OCTACOSANOL AFFECTS LIPID-METABOLISM IN RATS FED ON A HIGH-FAT DIET

被引：69

作者：

KATO, S ^{[1
]}

KARINO, KI ^{[1
]}

HASEGAWA, S ^{[1
]}

NAGASAWA, J ^{[1
]}

NAGASAKI, A ^{[1
]}

EGUCHI, M ^{[1
]}

ICHINOSE, T ^{[1
]}

TAGO, K ^{[1
]}

OKUMORI, H ^{[1
]}

HAMATANI, K ^{[1
]}

TAKAHASHI, M ^{[1
]}

OGASAWARA, J ^{[1
]}

MASUSHIGE, S ^{[1
]}

HASEGAWA, T ^{[1
]}

机构：

[1] SUMITOMO SEIKA CHEM CO L, CHUO KU, OSAKA 541, JAPAN

来源：

BRITISH JOURNAL OF NUTRITION | 1995年 / 73卷 / 03期

关键词：

OCTACOSANOL; LIPID METABOLISM; ADIPOSE TISSUE; SERUM TRIACYLGLYCEROL; RAT;

D O I：

10.1079/BJN19950045

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0.05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3.1.3.4). Though the activity of hormone-sensitive lipase (EC 3.1.1.3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3.1.1.34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.

引用

页码：433 / 441

页数：9

共 23 条

[1]

CURETON TK, 1972, PHYSL EFFECTS WHEAT, P525

[2] LIPOPROTEIN-LIPASE ACTIVITIES IN ADIPOSE TISSUES, HEART AND DIAPHRAGM OF GENETICALLY OBESE MOUSE (OB-OB) [J].