REGULATION OF MICROTUBULE DYNAMICS BY CDC2 PROTEIN-KINASE IN CELL-FREE-EXTRACTS OF XENOPUS EGGS

被引：410

作者：

VERDE, F

LABBE, JC

DOREE, M

KARSENTI, E

机构：

[1] European Molecular Biology Laboratory, Cell Biology Program, D-6900, Heidelberg

[2] CNRS, INSERM, 34033 Montpellier Cedex

来源：

NATURE | 1990年 / 343卷 / 6255期

关键词：

D O I：

10.1038/343233a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of ′ importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphase-metaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules. © 1990 Nature Publishing Group.

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页码：233 / 238

页数：6

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