CONCEPTS AND USEFULNESS OF PHARMACOKINETIC-PHARMACODYNAMIC MODELING

被引：13

作者：

HOLFORD, NHG

机构：

[1] Dept of Pharmacology and Clinical Pharmacology, University of Auckland

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1990年 / 4卷

关键词：

PHARMACOKINETICS; PHARMACODYNAMICS; MODELS;

D O I：

10.1111/j.1472-8206.1990.tb00067.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The combined application of pharmacokinetic and pharmacodynamic models to concentration and effect observations can be used to predict the consequences of alternative dosing strategies. Efficient experimental design is intimately related to the models that may be employed for data analysis. This is especially important in phase I studies which provide the basis for decisions on future clinical trials.

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收藏

页码：S93 / S101

页数：9

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