CONTROLLED-RELEASE INDOMETHACIN AND SUSTAINED-RELEASE DICLOFENAC SODIUM IN THE TREATMENT OF OSTEOARTHRITIS - A COMPARATIVE CONTROLLED CLINICAL-TRIAL IN GENERAL-PRACTICE

被引：21

作者：

GOSTICK, N ^{[1
]}

JAMES, IGV ^{[1
]}

KHONG, TK ^{[1
]}

ROY, P ^{[1
]}

SHEPHERD, PR ^{[1
]}

MILLER, AJ ^{[1
]}

机构：

[1] NAPP LABS LTD, CAMBRIDGE SCI PK, CAMBRIDGE CB4 4GW, ENGLAND

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 1990年 / 12卷 / 03期

关键词：

Delayed Action Preparations; Diclofenac Sodium; Indomethacin; Osteoarthritis;

D O I：

10.1185/03007999009111494

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A double-blind, crossover study was undertaken in general practice to compare the efficacy and tolerability of a new controlled-release indomethacin with sustained-release diclofenac sodium in patients with osteoarthritis. Eight-four patients were randomly allocated to receive controlled-release indomethacin tablets (75 mg) or sustained-release diclofenac sodium tablets (100 mg) at night for a period of 4 weeks before being crossed-over to receive the alternative treatment for a further 4 weeks. Pain scores for day and night, duration of morning stiffness, requirement for escape analgesia, and treatment preference were similar for both treatments. There was no significant difference between treatments for incidence and severity of side-effects. It was concluded that controlled-release indomethacin tablets (7.5 mg) given as a single night-time dose were as efficacious and well tolerated as sustained-release diclofenac sodium (100 mg). © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：135 / 142

页数：8

共 17 条

[11]

HART FD, 1987, DRUG TREATMENT RHEUM, P28

[12]

MARCOLONGO R, 1983, EUR J RHEUMATOL INFL, V6, P201

[13] EFFECTS ON UPPER GASTROINTESTINAL MUCOSA OF 3 DELIVERY SYSTEMS OF POTASSIUM AS SUPPLEMENT TO FRUSEMIDE ADMINISTRATION [J].

MCLOUGHLIN, JC .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1985, 78 (06) :459-462

[14]

MCLOUGHLIN JC, 1984, BRIT J CLIN PRACT, V38, P99

[15]

MUTRU O, 1978, SCAND J RHEUMATOL, P51

[16] A COMPARATIVE-STUDY OF NAPROXEN WITH DICLOFENAC SODIUM IN OSTEOARTHROSIS OF THE KNEES [J].

SCHARF, Y ;

NAHIR, M ;

SCHAPIRA, D ;

LORBER, M .

RHEUMATOLOGY AND REHABILITATION, 1982, 21 (03) :167-170

[17] DICLOFENAC (VOLTAREN) FOR TREATMENT OF OSTEO-ARTHROSIS - DOUBLE-BLIND COMPARISON WITH NAPROXEN [J].

SIRAUX, P .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1977, 5 (03) :169-174

← 1 2 →