BALANCED ANGIOTENSIN-II RECEPTOR ANTAGONISTS .3. THE EFFECTS OF SUBSTITUTION AT THE IMIDAZOLE 5-POSITION

被引：18

作者：

SANTELLA, JB ^{[1
]}

DUNCIA, JV ^{[1
]}

ENSINGER, CL ^{[1
]}

VANATTEN, MK ^{[1
]}

CARINI, DJ ^{[1
]}

WEXLER, RR ^{[1
]}

CHIU, AT ^{[1
]}

WONG, PC ^{[1
]}

TIMMERMANS, PBMWM ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,EXPTL STN,WILMINGTON,DE 19880

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)80077-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We wish to report on a series of substituted methyl esters and amides of DMP 811, which bind to both the AT(1) and AT(2) receptor subtypes. Some of the esters bind well to both receptor subtypes in the subnanomolar range when the optimal acid isostere is present together with an ortho-fluorine substituent on the biphenylmethyl group.

引用

页码：2235 / 2240

页数：6

共 16 条

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