1-(3-METHYL-2-BENZOXAZOLINONE-6-YL)-2-(4-SUBSTITUTED PIPERAZINE-1-YL)ETHANONES AND ETHANOLS - ANALGESIC AND ANTIINFLAMMATORY ACTIVITIES

Eight new 1-(3-methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-l-yl)ethanone and 1-(methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1 yl)ethanol derivatives were synthesized and their chemical structures elucidated by UV, IR, H-1-NMR and elemental analysis. The analgesic activity of these compounds was investigated by a modified Koster test and constant temperature hot-plate test. Antiinflammatory activity of the compounds was screened by using the carrageenan hind-paw edema test. All the compounds showed higher analgesic activity than aspirin. Carrageenan edema inhibition of the compounds was higher than indomethacin. None of the compounds induced gastric ulceration.