PHOTOCHEMICAL AND PHOTOSENSITIZING PROPERTIES OF MONOMERIC AND DIMERIC SN(IV)-PROTOPORPHYRIN

被引：12

作者：

REDDI, E ^{[1
]}

JORI, G ^{[1
]}

RUBALTELLI, FF ^{[1
]}

机构：

[1] UNIV PADUA,DEPT PEDIAT,I-35128 PADUA,ITALY

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1991年 / 8卷 / 02期

关键词：

TIN-PROTOPORPHYRIN; PHOTOSENSITIZATION; NEONATAL JAUNDICE; SINGLET OXYGEN;

D O I：

10.1016/1011-1344(91)80054-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sn(IV)-protoporphyrin IX (Sn-Pp) in aqueous media exists as a mixture of monomeric and dimeric species, which can be readily distinguished on the basis of their absorption maxima at around 410 and 386 nm respectively. Sn-Pp dimers prevail as the pH is decreased and are characterized by a lower fluorescence quantum yield, a larger tendency to undergo photobleaching and a reduced photosensitizing efficiency compared with the Sn-Pp monomer. The photosensitizing action of Sn-Pp appears to involve the intermediacy of singlet oxygen (O2)-O-1, as shown by photo-oxidation studies with N-acetyl-tryptophanamide in light and deuterated water solutions. Using 1,3-diphenyl-isobenzofuran as a substrate, the quantum yield of (O2)-O-1 generation by monomeric Sn-Pp was found to be about 0.6.

引用

页码：159 / 167

页数：9