PROLONGATION OF RAT CORNEAL GRAFT-SURVIVAL BY TREATMENT WITH ANTI-CD4 MONOCLONAL-ANTIBODY

被引：75

作者：

AYLIFFE, W ^{[1
]}

ALAM, Y ^{[1
]}

BELL, EB ^{[1
]}

MCLEOD, D ^{[1
]}

HUTCHINSON, IV ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CELL & STRUCT BIOL,IMMUNOL GRP,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1992年 / 76卷 / 10期

关键词：

D O I：

10.1136/bjo.76.10.602

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A rat model of orthotopic corneal graft rejection was used to investigate the effect of depletion of subpopulations of immune cells by treatment with monoclonal antibodies. Though CD4+ cells were not eliminated completely by anti-CD4 monoclonal antibodies there was a profound delay in the rejection times of orthotopic corneal allografts. Furthermore a third of the CD4+ depleted animals failed to reject corneal allografts by 100 days post grafting. Despite an almost complete depletion of circulating CD8+ cells, the anti-CD8 antibody treated animals rejected corneal allografts in a similar time course to allografted controls treated with a non-reactive control antibody OX21. These results demonstrate that CD8+ T-cells are not required for rejection of corneal allografts whereas CD4+ T-cells play a critical role in the rejection response. Treatment with anti-CD4 antibodies may have a useful clinical application.

引用

页码：602 / 606

页数：5