A CONSERVED RETINA-SPECIFIC GENE ENCODES A BASIC MOTIF LEUCINE ZIPPER DOMAIN

被引:274
作者
SWAROOP, A
XU, JZ
PAWAR, H
JACKSON, A
SKOLNICK, C
AGARWAL, N
机构
[1] UNIV MICHIGAN, KELLOGG EYE CTR, DEPT HUMAN GENET, ANN ARBOR, MI 48105 USA
[2] UNIV TEXAS, HLTH SCI CTR, DEPT PATHOL, SAN ANTONIO, TX 78284 USA
关键词
SUBTRACTION CLONING; DNA BINDING PROTEIN; V-MAF ONCOGENE; SIGNAL TRANSDUCTION; EVOLUTION;
D O I
10.1073/pnas.89.1.266
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Using subtraction cloning, we have isolated a human cDNA, AS321, which is expressed in retina and retinoblastoma cell lines but not in any other tissue or cell line tested. AS321 mRNA is detected in all cells of neural retina, with a high level of expression in photoreceptors. The polypeptide sequence deduced from the cDNA reveals consensus phosphorylation sites for protein kinase A and proline-directed protein kinase. Its C-terminal region contains a basic motif and a leucine zipper domain similar to the DNA binding proteins of the jun and fos oncoprotein family, and it shows a strong similarity to the product of an avian retroviral oncogene, v-maf. The gene for AS321 is conserved during evolution and is expressed in vertebrate retina. We propose to name the gene NRL (neural retina leucine zipper).
引用
收藏
页码:266 / 270
页数:5
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