GLOMERULAR NUMBER AND SIZE IN RELATION TO AGE, KIDNEY WEIGHT, AND BODY-SURFACE IN NORMAL MAN

被引：668

作者：

NYENGAARD, JR ^{[1
]}

BENDTSEN, TF ^{[1
]}

机构：

[1] AARHUS UNIV,INST EXPTL CLIN RES,INTERNAL MED CLIN 2,DK-8000 AARHUS,DENMARK

来源：

ANATOMICAL RECORD | 1992年 / 232卷 / 02期

关键词：

D O I：

10.1002/ar.1092320205

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The number and size of glomeruli in normal, mature human kidneys were estimated by a direct and unbiased stereological method, the fractionator. The number was 617,000 on average, and the mean size 6.0 M-mu-m3. Both glomerular number and size showed significant negative correlation to age and significant positive correlation to kidney weight. Apparently, humans loose glomeruli with age. Body surface area correlated positively to kidney weight and total glomerular volume but not to number of glomeruli. Body surface area correlates significantly with metabolic rate (Robertson and Reid, Lancet, 1: 940-943, 1952). Thus, intraspecies adaptation of kidney filtration capacity to the metabolic demand is performed by changing the size of glomeruli, i.e., the number of glomeruli in individuals of a given species is independent of the metabolic rate.

引用

页码：194 / 201

页数：8

共 46 条

[11]

ELIAS H, 1967, QUANTITATIVE METHODS

[12]

Ganong W.F, 1981, REV MED PHYSL

[13] GLOMERULAR SIZE AND STRUCTURE IN DIABETES-MELLITUS .2. LATE ABNORMALITIES [J].

GUNDERSEN, HJG ;

OSTERBY, R .

DIABETOLOGIA, 1977, 13 (01) :43-48

[14] NOTES ON ESTIMATION OF NUMERICAL DENSITY OF ARBITRARY PROFILES - EDGE EFFECT [J].

GUNDERSEN, HJG .

JOURNAL OF MICROSCOPY-OXFORD, 1977, 111 (NOV) :219-223

[15] STEREOLOGY OF ARBITRARY PARTICLES - A REVIEW OF UNBIASED NUMBER AND SIZE ESTIMATORS AND THE PRESENTATION OF SOME NEW ONES, IN MEMORY OF THOMPSON,WILLIAM,R. [J].

GUNDERSEN, HJG .

JOURNAL OF MICROSCOPY, 1986, 143 :3-45

[16] Experiments on the relation of creatinine and urea clearance tests of kidney function and the number of glomeruli in the human kidney obtained at autopsy [J].

Hayman, JM ;

Johnston, SM .

JOURNAL OF CLINICAL INVESTIGATION, 1933, 12 (05) :877-884

[17] THICKNESS VARIATIONS WITHIN INDIVIDUAL PARAFFIN AND GLYCOL METHACRYLATE SECTIONS [J].

HELANDER, KG .

JOURNAL OF MICROSCOPY-OXFORD, 1983, 132 (NOV) :223-227

[18] CORTICAL INTERSTITIAL-TISSUE AND SCLEROSED GLOMERULI IN THE NORMAL HUMAN-KIDNEY, RELATED TO AGE AND SEX - A QUANTITATIVE STUDY [J].

KAPPEL, B ;

OLSEN, S .

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1980, 387 (03) :271-277

[19]

KASISKE BL, 1986, ARCH PATHOL LAB MED, V110, P55

[20] GLOMERULAR SIZE AND STRUCTURE IN DIABETES-MELLITUS .3. EARLY ENLARGEMENT OF CAPILLARY SURFACE [J].

KROUSTRUP, JP ;

GUNDERSEN, HJG ;

OSTERBY, R .

DIABETOLOGIA, 1977, 13 (03) :207-210

← 1 2 3 4 5 →