INTRAMOLECULAR AMIDOALKYLATION OF AROMATICS .3. SYNTHESIS OF CONFORMATIONALLY RESTRICTED BRIDGED PEPTIDE ANALOGS OF PHE-GLY

被引：16

作者：

RABIBARAKAY, A ^{[1
]}

BENISHAI, D ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,DEPT CHEM,IL-32000 HAIFA,ISRAEL

来源：

TETRAHEDRON | 1994年 / 50卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(01)89269-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Derivatives of the Phe-alpha-methoxyglycine (4) were prepared and found to undergo stereospecific intramolecular amidoalkylation to give derivatives of 4-amino-2-benzazepin-3-one-1-carboxylic acid 5 (ABZC). The cyclic compounds 5a-g are conformationally restricted peptides containing a bridged Phe-Gly moiety.

引用

页码：10771 / 10782

页数：12

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