FUNCTIONS OF HIV ENVELOPE GLYCANS

被引：79

作者：

FENOUILLET, E ^{[1
]}

GLUCKMAN, JC ^{[1
]}

JONES, IM ^{[1
]}

机构：

[1] INST VIROL,OXFORD OX1 3SR,OXON,ENGLAND

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 02期

关键词：

D O I：

10.1016/0968-0004(94)90034-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unusually highly glycosylated state of the major envelope glycoprotein (gp160) of the human immunodeficiency virus has offered a challenge to both glycobiologists and virologists. What is the functional significance of such a mass of glycans and how might they be manipulated to disadvantage virus pathogenesis? Some answers to each of these questions have already been obtained: N-linked glycans are necessary for the creation, but not the maintenance, of a bioactive conformation, and drug-induced alteration of the glycosylation pattern can lead to impaired virus infectivity. As a model for studying glycan function and as a target for antiviral therapy, gp160 represents a unique candidate.

引用

页码：65 / 70

页数：6

共 47 条

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