CALCIUM SIGNALING IN PLATELETS AND OTHER CELLS

被引：95

作者：

HEEMSKERK, JWM

SAGE, SO

机构：

[1] UNIV LIMBURG,DEPT BIOCHEM,6200 MD MAASTRICHT,NETHERLANDS

[2] PHYSIOL LAB,CAMBRIDGE CB2 3EG,ENGLAND

来源：

PLATELETS | 1994年 / 5卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.3109/09537109409006439

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reviewed are new concepts and models of Ca2+ signalling originating from work with various animal cells, as well as the applicability of these models to the signalling systems used by blood platelets. The following processes and mechanisms are discussed: Ca2+ oscillations and waves; Ca2+-induced Ca2+ release; involvement of InsP(3)-receptors and quantal release of Ca2+ different pathways of phospholipase C activation; heterogeneity in the intracellular Ca2+ + stores; store- and receptor-regulated Ca2+ entry. Additionally, some typical aspects of Ca2+ + signalling in platelets are reviewed: involvement of protein serine/threonine and tyrosine kinases in the regulation of signal transduction; possible functions of platelet glycoproteins; and the importance of Ca2+ for the exocytotic and procoagulant responses,

引用

页码：295 / 316

页数：22

共 208 条

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