ANTI-AIDS AGENTS .22. ASYMMETRIC-SYNTHESIS OF 3',4'-DI-O-(-)-CAMPHANOYL-(+)-CIS-KHELLACTONE (DCK), A POTENT ANTI-HIV AGENT

被引：23

作者：

XIE, L

CRIMMINS, MT

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,DEPT CHEM,VENABLE & KENAN LABS CHEM,CHAPEL HILL,NC 27599

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

关键词：

D O I：

10.1016/0040-4039(95)00862-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient asymmetric synthesis of 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) (1) via catalytic asymmetric dihydroxylation is reported. Among seven commercial ligands investigated, (DHQ)(2)-PYR is the mast enantioselective ligand for the catalytic asymmetric dihydroxylation of seselin (5), a synthetic intermediate of DCK, and affords up to 86% e.e.

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页码：4529 / 4532

页数：4

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