DETERMINATION OF CHLORAL HYDRATE METABOLISM IN ADULT AND NEONATE BIOLOGICAL-FLUIDS AFTER SINGLE-DOSE ADMINISTRATION

被引：27

作者：

GORECKI, DKJ ^{[1
]}

HINDMARSH, KW ^{[1
]}

HALL, CA ^{[1
]}

MAYERS, DJ ^{[1
]}

SANKARAN, K ^{[1
]}

机构：

[1] UNIV SASKATCHEWAN,COLL MED,DEPT PEDIAT,SASKATOON S7N 0X0,SASKATCHEWAN,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 528卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0378-4347(00)82392-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, rapid and sensitive electron-capture gas chromatographic method has been developed for the simultaneous determination of chloral hydrate, trichloroethanol and trichloroacetic acid in biological fluids. The described method is applicable to single-dose pharmacokinetic studies of chloral hydrate in the adult. The method also meets the important requirement of using very small sample volumes and is sufficiently sensitive and reliable for disposition studies in the neonate. © 1990.

引用

页码：333 / 341

页数：9