TOTAL SYNTHESIS OF CERAMIDE TRIHEXOSIDE ACCUMULATING WITH FABRYS-DISEASE

被引：20

作者：

SHAPIRO, D

ACHER, AJ

机构：

[1] Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1978年 / 22卷 / 03期

关键词：

D O I：

10.1016/0009-3084(78)90026-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the synthesis of natural ceramide trihexoside, viz. gal (α-1 → 4) gal (β-1 → 4) gluc (β-1 → 1) ceramide (XIII). It involves the Koenigs-Knorr reaction of the bromide II with the aglucon XIX, and of the chloride VII with the D-enantiomer of the ceramide ester XII. A positional isomer of XIII was obtained as a by-product. A novel technique in the Koenings-Knorr reaction is described. © 1978.

引用

页码：197 / 206

页数：10