THE GLYCINE ANTAGONIST 7-CHLOROKYNURENIC ACID BLOCKS THE EFFECTS OF N-METHYL-D-ASPARTATE ON AGONIST-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN GUINEA-PIG BRAIN-SLICES

被引：7

作者：

KENDALL, DA

ROBINSON, JP

机构：

[1] Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 06期

关键词：

7‐Chlorokynurenic acid; Guinea‐pig; N‐methyl‐D‐aspartate; Phosphoinositide hydrolysis;

D O I：

10.1111/j.1471-4159.1990.tb05776.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: Despite having no effect on basal phosphoinositide hydrolysis, N‐methyl‐d‐aspartate (NMDA) inhibited carbachol‐stimulated accumulation of 3H‐inositol phosphates and enhanced that due to noradrenaline in guinea‐pig cerebral cortex slices. The glycine antagonist 7‐chlorokynurenic acid inhibited the effects of NMDA and this inhibition was reversed by glycine. The action of 7‐chlorokynurenic acid was not mimicked by strychnine or HA 966 (l‐hydroxy‐3‐aminopyrrolid‐2‐one). l‐Glutamate also inhibited carbacholstimulated accumulation of 3H‐inositol phosphates, but this inhibition was not blocked by 7‐chlorokynurenic acid. The data are consistent with glycine maintaining tonic control over NMDA receptor activity in guinea‐pig brain. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1915 / 1919

页数：5