ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS

被引：5560

作者：

HARDY, JA

HIGGINS, GA

机构：

[1] UNIV S FLORIDA, DEPT PSYCHIAT, TAMPA, FL 33612 USA

[2] NIA, BIOL CHEM LAB, BALTIMORE, MD 21224 USA

来源：

SCIENCE | 1992年 / 256卷 / 5054期

关键词：

D O I：

10.1126/science.1566067

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：184 / 185

页数：2

共 64 条

[1] INDUCTION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER HEAT-SHOCK IN CULTURED HUMAN LYMPHOBLASTOID-CELLS [J].

ABE, K ;

STGEORGEHYSLOP, PH ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :169-171

[2] SELECTIVE INDUCTION OF KUNITZ-TYPE PROTEASE INHIBITOR DOMAIN-CONTAINING AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER PERSISTENT FOCAL ISCHEMIA IN RAT CEREBRAL-CORTEX [J].

ABE, K ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :172-174

[3] EXACT CLEAVAGE SITE OF ALZHEIMER AMYLOID PRECURSOR IN NEURONAL PC-12 CELLS [J].

ANDERSON, JP ;

ESCH, FS ;

KEIM, PS ;

SAMBAMURTI, K ;

LIEBERBURG, I ;

ROBAKIS, NK .

NEUROSCIENCE LETTERS, 1991, 128 (01) :126-128

[4]

BAUDIER J, 1987, J BIOL CHEM, V262, P17577

[5] ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].

BLESSED, G ;

TOMLINSON, BE ;

ROTH, M .

BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+

[6] EARLY-ONSET ALZHEIMERS-DISEASE CAUSED BY MUTATIONS AT CODON-717 OF THE BETA-AMYLOID PRECURSOR PROTEIN GENE [J].

CHARTIERHARLIN, MC ;

CRAWFORD, F ;

HOULDEN, H ;

WARREN, A ;

HUGHES, D ;

FIDANI, L ;

GOATE, A ;

ROSSOR, M ;

ROQUES, P ;

HARDY, J ;

MULLAN, M .

NATURE, 1991, 353 (6347) :844-846

[7] CLEAVAGE OF AMYLOID-BETA PEPTIDE DURING CONSTITUTIVE PROCESSING OF ITS PRECURSOR [J].

ESCH, FS ;

KEIM, PS ;

BEATTIE, EC ;

BLACHER, RW ;

CULWELL, AR ;

OLTERSDORF, T ;

MCCLURE, D ;

WARD, PJ .

SCIENCE, 1990, 248 (4959) :1122-1124

[8] POTENTIALLY AMYLOIDOGENIC, CARBOXYL-TERMINAL DERIVATIVES OF THE AMYLOID PROTEIN-PRECURSOR [J].

ESTUS, S ;

GOLDE, TE ;

KUNISHITA, T ;

BLADES, D ;

LOWERY, D ;

EISEN, M ;

USIAK, M ;

QU, XM ;

TABIRA, T ;

GREENBERG, BD ;

YOUNKIN, SG .

SCIENCE, 1992, 255 (5045) :726-728

[9]

GANDY S, 1991, Journal of Cell Biology, V115, p122A

[10] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

← 1 2 3 4 5 6 7 →