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PEPTIDE-INDUCED CONFORMATIONAL-CHANGES IN CLASS-I HEAVY-CHAINS ALTER MAJOR HISTOCOMPATIBILITY COMPLEX RECOGNITION
被引:135
作者:
BLUESTONE, JA
JAMESON, S
MILLER, S
DICK, R
机构:
[1] UNIV CHICAGO, BEN MAY INST, COMM IMMUNOL, CHICAGO, IL 60637 USA
[2] UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA
[3] NORTHWESTERN UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, CHICAGO, IL 60611 USA
关键词:
D O I:
10.1084/jem.176.6.1757
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha1 and alpha2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity.
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页码:1757 / 1761
页数:5
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