SYNTHESIS OF A 9-MEMBERED RING VIA THE INTRAMOLECULAR NI(II)/CR(II)-MEDIATED COUPLING REACTION - UNUSUAL EFFECT OF CONCENTRATION ON THE COURSE OF THE REACTION

被引：26

作者：

BUSZEK, KR

JEONG, YM

机构：

[1] Department of Chemistry, Kansas State University, Manhattan

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 17期

关键词：

D O I：

10.1080/00397919408010554

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of a nine-membered ring by means of an intramolecular Ni(II)/Cr(II)-mediated coupling reaction between an iodoacetylene and an aldehyde is reported. The yield of the reaction is strongly dependent on the substrate concentration, but is independent of both the NiCl2 and CrCl2 concentration at high dilution. The application of this methodology to the synthesis of neocarzinostatin chromophore and other natural products is discussed.

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页码：2461 / 2472

页数：12

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