LIPASE-CATALYZED RESOLUTIONS OF SOME ALPHA,ALPHA-DISUBSTITUTED 1,2-DIOLS IN ORGANIC-SOLVENTS - NEAR ABSOLUTE REGIO AND CHIRAL RECOGNITION

被引：18

作者：

HOF, RP ^{[1
]}

KELLOGG, RM ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT ORGAN & MOLEC INORGAN CHEM,9747 AG GRONINGEN,NETHERLANDS

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1016/0957-4166(94)80019-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Several racemic 1,2-diols bearing a tertiary benzylic alcohol stereogenic center can be esterified regioselectively by vinyl acetate using lipases and esterases in organic media. With the correct choice of enzyme and if the non-phenyl substituent at the tertiary center is unsaturated, E values of > 250 can be achieved.

引用

页码：565 / 568

页数：4

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