NALOXONE REDUCES FLUID CONSUMPTION - RELATIONSHIP OF THIS EFFECT TO CONDITIONED TASTE-AVERSION AND MORPHINE-DEPENDENCE

Naloxone reduces fluid consumption in rats. It also produces a conditioned taste aversion (CTA). No reliable correlation was found between these two measures, suggesting that the reductions in drinking are unrelated to the illness-producing effects indexed by the CTA test. Measures of CTA using naloxone were also uncorrelated with measures of voluntary oral consumption of sweetened morphine solutions. In addition, naloxone suppression of drinking was unaffected by prior morphine administration with the administration of morphine given in a variety of ways, including dependence-producing regimens of injections. © 1979, The Psychonomic Society, Inc.. All rights reserved.