EFFECTS OF FISH-OIL ON SOME PARAMETERS OF FIBRINOLYSIS AND LIPOPROTEIN(A) IN HEALTHY-SUBJECTS

In summary, our studies show that (n-3) fatty acids consistently decrease triglyceride levels and increase PAI-1 activity and antigen levels without affecting t-PA levels. The reduction in lipoprotein(a) and fibrinogen levels with long-term intake of (n-3) fatty acids may have a bearing on their antiatherosclerotic and antithrombotic effects. The consistent increase in PAI-1 activity and antigen may be a nonspecific response to maintain vascular hemostasis. The addition of vitamin E may be important in overcoming the potentially deleterious oxidant effect of fish oil. © 1994.