THERAPEUTIC APPLICATIONS OF OLIGONUCLEOTIDES

被引：48

作者：

CROOKE, ST

机构：

[1] ISIS Pharmaceuticals, Carlsbad, CA, 92008

来源：

BIO-TECHNOLOGY | 1992年 / 10卷 / 08期

关键词：

D O I：

10.1038/nbt0892-882

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review focuses strictly on the pharmacodynamic considerations of the use of oligonucleotides designed to interact with nucleic acids as therapeutics. The objectives are to place oligonucleotide therapeutics in the context of modern drug discovery and development and to summarize recent progress.

引用

页码：882 / 886

页数：5

共 60 条

[21] GAO W, 1989, J BIOL CHEM, V264, P11521
[22] A C-MYB ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS NORMAL HUMAN HEMATOPOIESIS INVITRO
GEWIRTZ, AM
CALABRETTA, B
[J]. SCIENCE, 1988, 242 (4883) : 1303 - 1306
[23] ANTISENSE OLIGODEOXYRIBONUCLEOTIDES INHIBIT THE EXPRESSION OF THE GENE FOR HEPATITIS-B VIRUS SURFACE-ANTIGEN
GOODARZI, G
GROSS, SC
TEWARI, A
WATABE, K
[J]. JOURNAL OF GENERAL VIROLOGY, 1990, 71 : 3021 - 3025
[24] PRE-MESSENGER-RNA SPLICING
GREEN, MR
[J]. ANNUAL REVIEW OF GENETICS, 1986, 20 : 671 - 708
[25] SPECIFIC-INHIBITION OF LYMPHOKINE BIOSYNTHESIS AND AUTOCRINE GROWTH USING ANTISENSE OLIGONUCLEOTIDES IN TH1 AND TH2 HELPER T-CELL CLONES
HARELBELLAN, A
DURUM, S
MUEGGE, K
ABBAS, AK
FARRAR, WL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (06) : 2309 - 2318
[26] A C-MYC ANTISENSE OLIGODEOXYNUCLEOTIDE INHIBITS ENTRY INTO S-PHASE BUT NOT PROGRESS FROM G0 TO G1
HEIKKILA, R
SCHWAB, G
WICKSTROM, E
LOKE, SL
PLUZNIK, DH
WATT, R
NECKERS, LM
[J]. NATURE, 1987, 328 (6129) : 445 - 449
[27] CONCERNING ANTISENSE INHIBITION OF THE MULTIPLE-DRUG RESISTANCE GENE
JAROSZEWSKI, JW
KAPLAN, O
SYI, JL
SEHESTED, M
FAUSTINO, PJ
COHEN, JS
[J]. CANCER COMMUNICATIONS, 1990, 2 (08): : 287 - 294
[28] INHIBITION OF CELLULAR PROLIFERATION BY ANTISENSE OLIGODEOXYNUCLEOTIDES TO PCNA CYCLIN
JASKULSKI, D
DERIEL, JK
MERCER, WE
CALABRETTA, B
BASERGA, R
[J]. SCIENCE, 1988, 240 (4858) : 1544 - 1546
[29] SITE SPECIFICITY OF THE INHIBITORY EFFECTS OF OLIGO(NUCLEOSIDE METHYLPHOSPHONATE)S COMPLEMENTARY TO THE ACCEPTOR SPLICE JUNCTION OF HERPES-SIMPLEX VIRUS TYPE-1 IMMEDIATE EARLY MESSENGER RNA-4
KULKA, M
SMITH, CC
AURELIAN, L
FISHELEVICH, R
MEADE, K
MILLER, P
TSO, POP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) : 6868 - 6872
[30] SPECIFIC ANTIVIRAL ACTIVITY OF A POLY(L-LYSINE)-CONJUGATED OLIGODEOXYRIBONUCLEOTIDE SEQUENCE COMPLEMENTARY TO VESICULAR STOMATITIS-VIRUS N-PROTEIN MESSENGER-RNA INITIATION SITE
LEMAITRE, M
BAYARD, B
LEBLEU, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (03) : 648 - 652

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