CALCIUM-SENSITIVE UNIVALENT CATION CHANNEL FORMED BY LYSOTRIPHOSPHOINOSITIDE IN BILAYER LIPID-MEMBRANES

被引：17

作者：

HAYASHI, F

SOKABE, M

TAKAGI, M

HAYASHI, K

KISHIMOTO, U

机构：

[1] OSAKA UNIV,COLL GEN EDUC,DEPT BIOL,TOYONAKA,OSAKA 560,JAPAN

[2] OSAKA UNIV,FAC ENGN SCI,DEPT BIOPHYS ENGN,TOYONAKA,OSAKA 560,JAPAN

[3] GUMMA UNIV,FAC MED,DEPT BIOCHEM,GUMMA 371,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1978年 / 510卷 / 02期

关键词：

D O I：

10.1016/0005-2736(78)90031-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A calcium sensitive univalent cation channel could be formed by lysotriphosphoinositide on an artificial bilayer membrane made of oxidized cholesterol. The modified membrane was selectively permeable to univalent cations, but was only very sparingly permeable to anions or divalent cations. Selectivity sequence among group IA cations was Rb+ > Cs+ > Na+ > K+ > Li+. The conductance of the membrane was increased up to a value of about 10-2 ohm-1/cm2 with an increase in the concentration of univalent cation, and was drastically depressed by a relatively small increase in the concentration of calcium ion or other divalent cations. The sequence of depressing efficiency among divalent cations was Zn2+ > Cd2+ > Ca2+ > Sr2+ > Mg2+. © 1978.

引用

页码：305 / 315

页数：11

共 44 条

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