UNUSUAL ACCUMULATION OF COPPER RELATED TO INDUCTION OF METALLOTHIONEIN IN THE LIVER OF LEC RATS

被引:47
作者
SAKURAI, H
FUKUDOME, A
TAWA, R
KITO, M
TAKESHIMA, S
KIMURA, M
OTAKI, N
NAKAJIMA, K
HAGINO, T
KAWANO, K
HIRAI, S
SUZUKI, S
机构
[1] NATL INST IND HLTH SCI,KANAGAWA 211,JAPAN
[2] JAPAN IMMUNORES LABS CO,GUMMA 370,JAPAN
[3] OTUKA PHARMACEUT CO,TOKUSHIMA RES INST,TOKUSHIMA 77101,JAPAN
[4] MUSASHI INST TECHNOL,ATOM RES LAB,KANAGAWA 215,JAPAN
[5] KEIO UNIV,SCH MED,TOKYO 160,JAPAN
关键词
D O I
10.1016/S0006-291X(05)80037-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Copper (Cu), iron (Fe), zinc (Zn) and manganese (Mn) levels in organs of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatisis, were determined by instrumental neutron activation analysis method. Unusual accumulations of Cu in the liver of LEC rats were found, depending on the age of the animals, the metal concentration being more than approximately 20-40 times those of normal LEA rats (Long-Evens rats with an agouti coat color). Fe and Zn were also accumulated, in addition to Cu, significantly in the LEC rats. The unusual Cu accumulations in the liver of LEC rats were associated with the induction of metallothionein, estimated by radioimmunoassay method, in the liver of LEC rats, rather than that of superoxide dismutase, estimated by electron spin resonance -spin trapping method. These findings suggest that the unusual Cu accumulation in LEC rats is involved in the development of jaundice, hepatic injury and hepatocellular carcinoma. © 1992 Academic Press, Inc.
引用
收藏
页码:1393 / 1397
页数:5
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