THE OVARIAN INSULIN AND INSULIN-LIKE GROWTH-FACTOR SYSTEM WITH AN EMPHASIS ON DOMESTIC-ANIMALS

被引：378

作者：

SPICER, LJ ^{[1
]}

ECHTERNKAMP, SE ^{[1
]}

机构：

[1] USDA ARS, MEAT ANIM RES CTR, CLAY CTR, NE 68933 USA

来源：

DOMESTIC ANIMAL ENDOCRINOLOGY | 1995年 / 12卷 / 03期

关键词：

D O I：

10.1016/0739-7240(95)00021-6

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Insulin and insulin-like growth factors (IGFs) have direct effects on cultured ovarian cells. These effects include stimulation of granulosa cell mitogenesis, granulosa and luteal cell progesterone production, and thecal cell androgen production and appear similar among species. However, species differences exist with regard to insulin and IGF-I effects on granulosa cell estradiol production. In addition to endocrine effects of insulin and IGFs, IGFs are produced by granulosa, thecal, and luteal cells, allowing for an intraovarian autocrine and paracrine system. Granulosa, thecal, and luteal cells contain receptors for insulin and IGFs, and these receptors appear to mediate the effects of insulin and IGFs. Adding to the complexity of the regulatory role of IGFs is the presence of IGF-binding proteins (IGFBPs) within the ovary. These IGFBPs are produced by granulosa, thecal, and luteal cells, and their production is hormonally regulated. Evidence for a coherent mechanism by which insulin, IGFs, and IGFBPs interact and regulate ovarian function in vivo has yet to be found.

引用

页码：223 / 245

页数：23

共 182 条

[1]

AASHI EY, 1986, J BIOL CHEM, V261, P3923

[2]

ADASHI EY, 1989, SERONO SYMP, P95

[3] OVARIAN GRANULOSA CELL-DERIVED INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS - MODULATORY ROLE OF FOLLICLE-STIMULATING-HORMONE [J].