TOTAL SYNTHESES OF CLOSE ANALOGS OF THE IMMUNOSUPPRESSANT FK506

被引：20

作者：

BATCHELOR, MJ

GILLESPIE, RJ

GOLEC, JMC

HEDGECOCK, CJR

JONES, SD

MURDOCH, R

机构：

[1] Roussel Laboratories Ltd, Swindon, Wiltshire SN3 5BZ England, Kingfisher Drive, Covingham

来源：

TETRAHEDRON | 1994年 / 50卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(01)80796-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of an analogue of FK506, in which the substituted cyclohexyl residue at C-28 has been replaced by a phenyl group, is described. This synthesis demonstrates (i) the successful application of new methodology for the introduction of the masked tricarbonyl grouping (C-8-C-10), and(ii) new synthetic routes to the (C-10-C-19) and (C-22-C-26) regions.

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页码：809 / 826

页数：18

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