机构:Stanley J. Korsmeyer is at the Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
KORSMEYER, SJ
机构:
[1] Stanley J. Korsmeyer is at the Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
来源:
IMMUNOLOGY TODAY
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1992年
/
13卷
/
08期
关键词:
D O I:
10.1016/0167-5699(92)90037-8
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The genes and mechanisms that control programmed cell death are currently the subject of intense study. The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes. Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.