ADVANTAGEOUS APPLICATIONS OF AZABENZOTRIAZOLE (TRIAZOLOPYRIDINE)-BASED COUPLING REAGENTS TO SOLID-PHASE PEPTIDE-SYNTHESIS

被引：386

作者：

CARPINO, LA ^{[1
]}

EL-FAHAM, A ^{[1
]}

MINOR, CA ^{[1
]}

ALBERICIO, F ^{[1
]}

机构：

[1] MILLIPORE CORP, BEDFORD, MA 01730 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 02期

关键词：

D O I：

10.1039/c39940000201

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

1-Hydroxy-7-azabenzotriazole (HOAt) and its corresponding uronium and phosphonium salts are shown to be superior to their benzotriazole analogs in solid-phase peptide synthesis, thereby making possible the automated synthesis of peptides containing hindered amino acids.

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页码：201 / 203

页数：3

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