SURFACE CHARACTERIZATION OF HEPARIN-COMPLEXING POLY(AMIDO AMINE) CHAINS GRAFTED ON POLYURETHANE AND GLASS SURFACES

被引:12
作者
BARBUCCI, R
BASZKIN, A
BENVENUTI, M
COSTA, MD
FERRUTI, P
机构
[1] UNIV PARIS SUD,CNRS,UNITE PHYSICOCHIM SURFACES & INNOVAT PHARMACOTECHNIE 1218,F-92296 CHATENAY MALABRY,FRANCE
[2] UNIV SIENA,CTR DIDATTICO,CRISMA,I-53100 SIENA,ITALY
[3] UNIV BRESCIA,FAC INGN,I-25060 BRESCIA,ITALY
来源
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1987年 / 21卷 / 04期
关键词
BIOMEDICAL ENGINEERING - Cardiovascular Surgery - GLASS - Surfaces - POLYURETHANES - Surfaces - PROSTHETICS - Grafts;
D O I
10.1002/jbm.820210405
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(amido-amine) chains grafted onto polyurethanes and glass form stable complexes with heparin yielding potential nonthrombogenic surfaces. The characterization of the surfaces, and the product of each chemical reaction including final heparinized surfaces, has been studied by contact angle data and scanning electron microscopy (SEM). Air in water, octane in water, and drop-on-plate contact angle data were used to estimate surface and interfacial free energies. Solid-water work of adhesion and its dispersive and polar components were calculated for all studied surfaces. It has been found that the viscosity of polyurethane solution used for film casting influences wetting properties of these films. It has also been found that a direct correlation exists between the polar and dispersive values and the degree of coverage of the surfaces by cellular deposits after their exposure to platelet-rich plasma. Final heparinized polyurethane and glass materials are hydrophilic, their polar/dispersive ratio is high, and little or no cellular deposit is observed on their surfaces.
引用
收藏
页码:443 / 457
页数:15
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