COEXPRESSION OF ENDOTHELIAL-CELL AND MACROPHAGE ANTIGENS IN KAPOSIS-SARCOMA CELLS

被引：68

作者：

UCCINI, S

RUCO, LP

MONARDO, F

STOPPACCIARO, A

DEJANA, E

LAPAROLA, IL

CERIMELE, D

BARONI, CD

机构：

[1] IST RIC FARMACOL MARIO NEGRI,MILAN,ITALY

[2] UNIV CATTOLICA SACRO CUORE,DEPT DERMATOL,ROME,ITALY

来源：

JOURNAL OF PATHOLOGY | 1994年 / 173卷 / 01期

关键词：

KAPOSIS SARCOMA; AIDS; ENDOTHELIAL CELL; MACROPHAGE; ADHESION MOLECULE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1002/path.1711730105

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (VWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM-1, CD68, and CD14, and were positive for vitronectin receptor and alpha-1,5,6/beta-1 integrins. KS cells were weakly stained for ICAM-1 in 6 of 12 cases and were negative for VCAM-1 and E-selectin.

引用

页码：23 / 31

页数：9

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