ANALYSIS OF ALUMINUM IN PHARMACEUTICAL PRODUCTS BY POSTCOLUMN DERIVATIZATION ION CHROMATOGRAPHY

被引：15

作者：

CARNEVALE, J ^{[1
]}

JACKSON, PE ^{[1
]}

机构：

[1] WATERS CHROMAT DIV MILLIPORE,LANE COVE,NSW 2066,AUSTRALIA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 671卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)80229-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aluminium can be determined in pharmaceutical products using a chromatographic method with a cation-exchange separation and fluorescence detection after post-column derivatization with 8-hydroxyquinoline-5-sulphonic acid. The method had a detection limit of less than 0.5 ng/ml and the aluminium peak response was linear up to at least 1200 ng/ml. Chromatographic reproducibility was approximately 1-3% over the concentration range of 50-1200 ng/ml. Sample preparation involved boiling in 0.05 M sulphuric acid for 5 min. The average recovery for Al spikes in the range 10-1200 ng/ml, from a variety of pharmaceutical samples, was 99% with an R.S.D. of 5%. No interferences from either sample matrix effects or transition metals were found and the results of the chromatographic method agreed well with those obtained by inductively coupled plasma atomic emission spectroscopy.

引用

页码：115 / 120

页数：6

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