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DETAILED PHYSICAL MAP OF HUMAN CHROMOSOMAL REGION 11Q12-13 SHOWS HIGH MEIOTIC RECOMBINATION RATE AROUND THE MEN1 LOCUS

被引：66
作者：
JANSON, M
LARSSON, C
WERELIUS, B
JONES, C
GLASER, T
NAKAMURA, Y
JONES, CP
NORDENSKJOLD, M
机构：
[1] ELEANOR ROOSEVELT INST CANC RES,DENVER,CO 80206
[2] HARVARD UNIV,SCH MED,HOWARD HUGHES MED CTR,BOSTON,MA 02115
[3] JAPANESE FDN CANC RES,INST CANC,TOSHIMA KU,TOKYO 170,JAPAN
[4] MRC,MOLEC GENET UNIT,CAMBRIDGE CB2 4QH,ENGLAND
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 23期
关键词：
GENE MAPPING; PULSED-FIELD GEL ELECTROPHORESIS; RADIATION-REDUCED SOMATIC CELL HYBRIDS; MULTIPLE ENDOCRINE NEOPLASIA TYPE-1;
D O I：
10.1073/pnas.88.23.10609
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have constructed a physical map of the region q12-13 on chromosome 11 by combining data generated from a panel of radiation-reduced somatic cell hybrids and pulsed-field gel electrophoresis (PFGE). Twenty different genetic markers have been sublocalized and ordered within this region and a total of 8.0 megabases has been mapped in detail using rare-cutting restriction endonucleases and PFGE. In two instances, the long-range restriction PFGE map spans the total distance between pairs of loci that have been previously mapped by genetic linkage in reference families. Comparison of this physical map with the available linkage map indicates a great variation in the recombination frequency over the region. The recombination rate is higher than expected, particularly for markers nanking the MEN1 region. Thus, for the closest pair of linked markers on the centromeric side, one centimorgan corresponds to almost-equal-to 300 kilobases, and for markers on the telomeric side, one centimorgan corresponds to almost-equal-to 350-600 kilobases.
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页码：10609 / 10613
页数：5
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