LOCALIZATION OF THE GENE ENCODING A TYPE-1 PROTEIN PHOSPHATASE CATALYTIC SUBUNIT TO HUMAN-CHROMOSOME BAND-11Q13

被引：82

作者：

BARKER, HM

JONES, TA

SILVA, EFD

SPURR, NK

SHEER, D

COHEN, PTW

机构：

[1] IMPERIAL CANC RES FUND,POTTERS BAR EN6 3LD,HERTS,ENGLAND

[2] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

来源：

GENOMICS | 1990年 / 7卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0888-7543(90)90536-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cDNA encoding one isoform (PP1α) of the catalytic subunit of human protein phosphatase 1 has been isolated and used to map the human PP1α gene (PPP1A) to chromosome band 11q13 by analysis of somatic cell hybrids and in situ hybridization. Neoplasms that map to 11q13 are discussed in the light of the recent findings that PP1α is a putative tumor suppressor and that it plays a key role in the control of mitosis. © 1990.

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页码：159 / 166

页数：8

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