EFFECT OF COLLOIDAL CARRIERS ON THE DISPOSITION AND TISSUE UPTAKE OF DOXORUBICIN .2. CONJUGATION WITH ISOBUTYLCYANOACRYLATE NANOPARTICLES

被引:2
作者
BAPAT, N [1 ]
BOROUJERDI, M [1 ]
机构
[1] NORTHEASTERN UNIV,DEPT PHARMACEUT SCI,BOSTON,MA 02115
关键词
D O I
10.3109/03639049309050170
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The effect of isobutylcyanoacrylate nanoparticles, in the size range of 100-220nm, on the disposition of doxorubicin was investigated. After intravenous injection of drug-containing nanoparticles into rats, the plasma concentration showed an initial rapid rise before a biphasic decline. The rate of the breakdown of the polymer was found to be much slower than the anticipated value. Urine flow declined significantly after injection. The concentration of drug in the liver, kidney, lung and spleen was lower than the control and did not increase over time. The low concentration may be attributed to the slow breakdown of the polymer in the body and slow release of the drug associated with the matrix of the carrier. The association of doxorubicin with the nanoparticles alters pharmokintics of the drug in ways that could provide optimal condition for drug distribution within the systemic circulation and a therapeutic effect with a lesser probability of cardiotoxicity.
引用
收藏
页码:2667 / 2678
页数:12
相关论文
共 15 条
[1]   ADSORPTION-ISOTHERM FOR DOXORUBICIN ON ERYTHROCYTE-MEMBRANE [J].
ALACHI, A ;
BOROUJERDI, M .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1990, 16 (08) :1325-1338
[2]   UPTAKE CAPACITY AND ADSORPTION-ISOTHERMS OF DOXORUBICIN ON POLYMERIC NANOPARTICLES - EFFECT OF METHODS OF PREPARATION [J].
BAPAT, N ;
BOROUJERDI, M .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (01) :65-77
[3]   POLYALKYLCYANOACRYLATE NANOPARTICLES AS DRUG CARRIER - PRESENT STATE AND PERSPECTIVES [J].
COUVREUR, P ;
VAUTHIER, C .
JOURNAL OF CONTROLLED RELEASE, 1991, 17 (02) :187-198
[4]  
COUVREUR P, 1992, J CONTROL RELEASE, V19, P259, DOI 10.1016/0168-3659(92)90081-2
[5]   TOXICITY OF POLYALKYLCYANOACRYLATE NANOPARTICLES .2. DOXORUBICIN-LOADED NANOPARTICLES [J].
COUVREUR, P ;
KANTE, B ;
GRISLAIN, L ;
ROLAND, M ;
SPEISER, P .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (07) :790-792
[6]   POLYCYANOACRYLATE NANOCAPSULES AS POTENTIAL LYSOSOMOTROPIC CARRIERS - PREPARATION, MORPHOLOGICAL AND SORPTIVE PROPERTIES [J].
COUVREUR, P ;
KANTE, B ;
ROLAND, M ;
GUIOT, P ;
BAUDUIN, P ;
SPEISER, P .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (05) :331-332
[7]   APPROACHES TO RADIOLABELING OF ANTIBODIES FOR DIAGNOSIS AND THERAPY OF CANCER [J].
FRITZBERG, AR ;
BERNINGER, RW ;
HADLEY, SW ;
WESTER, DW .
PHARMACEUTICAL RESEARCH, 1988, 5 (06) :325-334
[8]   TOXICITY OF POLYALKYLCYANOACRYLATE NANOPARTICLES .1. FREE NANOPARTICLES [J].
KANTE, B ;
COUVREUR, P ;
DUBOISKRACK, G ;
DEMEESTER, C ;
GUIOT, P ;
ROLAND, M ;
MERCIER, M ;
SPEISER, P .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (07) :786-790
[9]   INVITRO STUDIES OF POLY(METHYL METHACRYLATE) ADJUVANTS [J].
KREUTER, J ;
SPEISER, PP .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (11) :1624-1627
[10]  
KREUTER J, 1983, PHARM ACTA HELV, V58, P217