THE TIPS/TINS LECTURE - THE MOLECULAR-BIOLOGY OF MAMMALIAN GLUTAMATE-RECEPTOR CHANNELS

被引：225

作者：

SEEBURG, PH

机构：

[1] Centre of Molecular Biology (ZMBH), Laboratory of Molecular Neuroendocrinology, 69052 Heidelberg, PO Box 10 62 49

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 08期

关键词：

D O I：

10.1016/0165-6147(93)90047-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has revealed the existence of 16 channel subunits that can assemble in homomeric or heteromeric configurations in vitro to form receptor channels with disparate functional properties. This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures.

引用

页码：297 / 303

页数：7

共 74 条

[61] SINGLE-CHANNEL CONDUCTANCES OF NMDA RECEPTORS EXPRESSED FROM CLONED CDNAS - COMPARISON WITH NATIVE RECEPTORS
STERN, P
BEHE, P
SCHOEPFER, R
COLQUHOUN, D
[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1992, 250 (1329) : 271 - 277
[62] STERN P, 1992, J PHYSL, V13, P291
[63] STRUCTURES AND PROPERTIES OF 7 ISOFORMS OF THE NMDA RECEPTOR GENERATED BY ALTERNATIVE SPLICING
SUGIHARA, H
MORIYOSHI, K
ISHII, T
MASU, M
NAKANISHI, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (03) : 826 - 832
[64] TOLLE TR, IN PRESS J NEUROSCI
[65] GLUTAMATE RECEPTOR DESENSITIZATION AND ITS ROLE IN SYNAPTIC TRANSMISSION
TRUSSELL, LO
FISCHBACH, GD
[J]. NEURON, 1989, 3 (02) : 209 - 218
[66] NICOTINIC ACETYLCHOLINE-RECEPTOR AT 9-ANGSTROM RESOLUTION
UNWIN, N
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1993, 229 (04) : 1101 - 1124
[67] AMPLIFIED RNA SYNTHESIZED FROM LIMITED QUANTITIES OF HETEROGENEOUS CDNA
VANGELDER, RN
VONZASTROW, ME
YOOL, A
DEMENT, WC
BARCHAS, JD
EBERWINE, JH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (05) : 1663 - 1667
[68] STRUCTURAL DETERMINANTS OF ION FLOW THROUGH RECOMBINANT GLUTAMATE RECEPTOR CHANNELS
VERDOORN, TA
BURNASHEV, N
MONYER, H
SEEBURG, PH
SAKMANN, B
[J]. SCIENCE, 1991, 252 (5013) : 1715 - 1718
[69] DEVELOPMENTAL-CHANGES IN DISTRIBUTION OF NMDA RECEPTOR CHANNEL SUBUNIT MESSENGER-RNAS
WATANABE, M
INOUE, Y
SAKIMURA, K
MISHINA, M
[J]. NEUROREPORT, 1992, 3 (12) : 1138 - 1140
[70] STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF EXCITATORY AMINO-ACID RECEPTOR AGONISTS AND COMPETITIVE ANTAGONISTS
WATKINS, JC
KROGSGAARDLARSEN, P
HONORE, T
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (01) : 25 - 33

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