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NADPH OXIDASE AND THE RESPIRATORY BURST

被引：88
作者：
WIENTJES, FB
SEGAL, AW
机构：
[1] Division of Molecular Medicine, Department ofMedicine, University College London, London, WC1E 6JJ
来源：
SEMINARS IN CELL BIOLOGY | 1995年 / 6卷 / 06期
基金：
英国惠康基金;
关键词：
PHAGOCYTES; RESPIRATORY BURST; NADPH OXIDASE; PROTEIN INTERACTIONS; SMALL G-PROTEINS;
D O I：
10.1016/S1043-4682(05)80006-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in, killing microorganisms. Patients suffering from granulomatous disease (CGD), in which this system is failing, are abnormally susceptible to infectious diseases. Studying CGD patients' neutrophils has been enormously helpful in identifying the components of the superoxide-generating system, known as the NADPH oxidase. This review will describe the components of the electron-transport chain involved in the oxidase and the factors needed for its regulation.
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收藏
页码：357 / 365
页数：9
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