MOLECULAR-CLONING OF A NOVEL PUTATIVE G-PROTEIN-COUPLED RECEPTOR EXPRESSED IN THE CARDIOVASCULAR-SYSTEM

被引：134

作者：

OKAZAKI, H

ISHIZAKA, N

SAKURAI, T

KUROKAWA, K

GOTO, K

KUMADA, M

TAKUWA, Y

机构：

[1] UNIV TOKYO,FAC MED,DEPT CARDIOVASC BIOL,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT INTERNAL MED,TOKYO 113,JAPAN

[3] UNIV TOKYO,FAC MED,DEPT PHYSIOL,TOKYO 113,JAPAN

[4] UNIV TSUKUBA,INST BASIC MED SCI,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel cDNA clone encoding a putative G protein-coupled receptor has been isolated from a rat aortic smooth muscle cDNA library. Sequence analysis of this clone reveals the structural features characteristic of this superfamily, with a high degree of sequence similarity to the Edg-1 receptor previously reported to be expressed in vascular endothelial cells. This novel receptor mRNA is expressed predominantly in the lung and heart. Although the ligand for this receptor has yet to be identified, the results suggest the existence of a new receptor subfamily in the cardiovascular system thus far unrecognized. © 1993 Academic Press, Inc.

引用

页码：1104 / 1109

页数：6

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