ELEMENTAL IMBALANCES IN THE OLFACTORY PATHWAY IN ALZHEIMERS-DISEASE

被引：112

作者：

SAMUDRALWAR, DL

DIPRETE, CC

NI, BF

EHMANN, WD

MARKESBERY, WR

机构：

[1] UNIV KENTUCKY, DEPT PATHOL, LEXINGTON, KY 40506 USA

[2] UNIV KENTUCKY, DEPT CHEM, LEXINGTON, KY 40506 USA

[3] UNIV KENTUCKY, DEPT NEUROL, LEXINGTON, KY 40506 USA

[4] UNIV KENTUCKY, MED CTR, SANDERS BROWN CTR AGING, LEXINGTON, KY 40536 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 130卷 / 02期

关键词：

ALZHEIMERS DISEASE; OLFACTORY PATHWAY; TRACE ELEMENTS; NEUTRON ACTIVATION ANALYSIS;

D O I：

10.1016/0022-510X(95)00018-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Concentrations of 11 trace elements were determined in 56 control and 98 Alzheimer's disease (PLD) olfactory bulb, olfactory tract, olfactory trigone, piriform cortex and amygdala specimens by instrumental neutron activation analysis. Iron and zinc were significantly elevated and bromine was significantly depleted in olfactory regions of AD patients, compared with normal age-matched control subjects. Elevated iron could possibly play a role in neuronal degeneration in AD by enhancing reactive free radical formation.

引用

页码：139 / 145

页数：7

共 63 条

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